摘要 |
<p>The use of hesperidin (I) or its salts in the production of medicaments for the prophylaxis and treatment of Alzheimer's disease or Parkinson's disease. ACTIVITY : Neuroprotective; Nootropic; Antiparkinsonian. MECHANISM OF ACTION : Cholinergic, noradrenergic and dopaminergic neurotransmission mediator. In tele-stereo-EEG tests in rats (see Eur. J. Med. Res. (2003) 8; 1990-207), (I) at intraperitoneal doses of 80 or 160 mg/kg caused significant, dose-dependent changes in electrical activity in the brain, with a stable pattern over a long period. At 160 mg/kg (I) caused a reduction in the delta wave (cholinergic), tau wave (noradrenergic) and alpha 2 wave (dopaminergic) frequencies, starting within the first hour and maintained during the full 5 hours of the test. The pattern correlated well with those obtained with known drugs for treating neurodegenerative drugs, e.g. tacrin, piracetam or memantine.</p> |