发明名称 |
FREEZE-DRIED PREPARATION CONTAINING METHYLCOBALAMIN AND PROCESS FOR PRODUCING THE SAME |
摘要 |
<p>The present invention provides a freeze-dried preparation containing a high content of methylcobalamin which is highly stable over time and can be used in high-concentration methylcobalamin therapy. Disclosed is the freeze-dried preparation containing methylcobalamin or a pharmacologically acceptable salt thereof and an excipient wherein the excipient is at least in an amorphous state. The freeze-dried preparation according to the present invention is characterized in that when the excipient comprises a sugar and a sugar alcohol, the excipient in the amorphous state is contained in an amount of at least 20% by weight, based on the total weight of the sugar and the sugar alcohol.</p> |
申请公布号 |
EP1621202(A1) |
申请公布日期 |
2006.02.01 |
申请号 |
EP20040731472 |
申请日期 |
2004.05.06 |
申请人 |
EISAI CO., LTD. |
发明人 |
KATO, AKIRA;NOMURA, TERUKO |
分类号 |
A61K9/00;A61K9/19;A61K31/714;A61K47/02;A61K47/10;A61K47/26;A61P25/00;(IPC1-7):A61K31/714 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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