QUINOLINE DERIVATIVES AS CASPASE-3 INHIBITOR, PREPARATION FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

摘要

The present invention relates to new quinoline derivatives of formula (1) or their pharmaceutically acceptable salts with caspase-3 inhibitory activity and their preparation methods, wherein R₂ is H; halogen; C_1-6alkyl; C_1-6 alkoxy; C_1-6 alkoxyalkyl; or C_3-6cycloalkyl; R₁ is formula (a); -CN; or formula (b); R is H; C_6-14aryl unsubstituted or substituted by halogen, C_1-6 alkyl, C_1-6 alkoxy or amino; 5-15 membered heterocyclic group unsubstituted or substituted by halogen, C_1-6 alkyl, C_1-6 alkoxy or amino; or -(CH₂)_n-CHR₄R₅. The present invention relates to a pharmaceutical composition for treating caspase-associated diseases by inhibiting the activity of caspase-3 which comprises the compound of formula (1) or its pharmaceutically acceptable salt.