Peptide ligands specific to immonoglobulins

摘要

A compound of formula:
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ (X 1 -X 2 -His-X 3 -CO) n -R€ƒ€ƒ€ƒ€ƒ€ƒ(I)
where: X 1 is H or an amino acid residue of cysteine (Cys) having L or D configuration, wherein each pair of amino acid residues of Cys, optionally present as X 1 , can be in the form of a cystine residue owing to an -S-S- bridge formed by the -SH functions of two Cys residues, X 2 is an amino acid residue of tyrosine (Tyr) or of histidine (His) having L or D configuration, X 3 is an amino acid res 2 is Tyr when X 3 is His and X 2 is His when X 3 is Tyr, His is an amino acid residue of histidine having L or D configuration, n is an integer of from 1 to 4, R when n is 1, is OH, a residue of a single amino acid, or a peptide chain comprising from 2 to 7 amino acids, €ƒ€ƒ€ƒ
whereas,
when n is 2, 3 or 4, it is a group capable of forming a dimer, a trimer and, respectively, a tetramer.