发明名称 |
MODIFIED INTERLEUKIN-1 RECEPTOR ANTAGONIST (IL-1RA) WITH REDUCED IMMUNOGENICITY |
摘要 |
The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The invention in particular relates to the modification of interleukin-1 receptor antagonist (IL-1RA) to result in IL-1RA proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo. |
申请公布号 |
HU0400698(A3) |
申请公布日期 |
2006.01.30 |
申请号 |
HU20040000698 |
申请日期 |
2002.02.05 |
申请人 |
MERCK PATENT GMBH, DARMSTADT |
发明人 |
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分类号 |
C12N15/09;A61K9/70;A61K38/00;A61K38/11;A61K38/20;A61K45/00;A61K47/02;A61K47/12;A61P37/00;A61P43/00;C07K7/06;C07K7/08;C07K14/47;C07K14/54;C07K16/18;C07K16/28;C07K16/30;C07K16/46;C12N15/17;C12P21/02;G06F19/16;G06F19/18 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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