| 摘要 |
<p>Disclosed are methods for preparing 2-alkynyladenosine derivatives of Formula (A): or a stereoisomer, pharmaceutically acceptable salt, hydrate, solvate, acid salt hydrate or isomorphic crystalline form thereof, the method comprising the step ofcontacting 2-iodoadenosine-5'-N-ethyluronamide with a compound of Formula (B): wherein Z is -C(=O)OR or -CH20C(=O)R, where R is a C1 to C5 alkyl, preferably methyl. The methods are useful for preparing 2 --alkynyladenosine derivatives that are, in certain embodiments, adenosine receptor agonists.</p> |
