| 摘要 |
FIELD: veterinary pharmacology. ^ SUBSTANCE: The suggested method deals with interaction of valerianic acid anhydride with steroid alcohol - 17alpha-acetoxy-3beta-hydroxy-6-methylpregna-4.6-dien-20-on at molar ratio being 1.1-1.5:1 to steroid, which should be implemented in pyridine medium in volume-weight ratio of 1.5-2.0:1 pyridine to steroid at 22-25°C, excess of anhydride should be hydrolyzed with water at the quantity of 15-20% against the volume of reaction mass, as for developed valerianic acid, it should be dissolved in 1-1.5%-ammonia aqueous solution and a target product should be filtered, washed with water up to neutral reaction to be washed with methanol. The innovation provides obtaining new target product of higher purification degree. ^ EFFECT: higher efficiency. ^ 7 ex, 7 tbl |
