| 摘要 |
<p>It is intended to provide an IL-18 receptor antibody which serves as an IL-18 receptor antagonist and is immunohistochemically usable; and a pharmaceutical composition and a method for preventing and/or treating IL-18-dependent disorders, in particular, skin thickening caused by ultraviolet rays with the use of the above antibody. Namely, an antibody against IL-18 receptor a subunit characterized by being capable of specifically binding to a polypeptide comprising the amino acid sequence represented by SEQ ID NO:1, or an antibody against IL-18 receptor ß subunit characterized by being capable of specifically binding to a polypeptide comprising the amino acid sequence represented by SEQ ID NO:2 is constructed.</p> |
