Immunostimulatory nucleic acids for inducing IL-10 responses

摘要

The invention relates to methods and products for inducing IL-10 expression using immunostimulatory nucleic acids. In particular, the invention relates to methods and products for inducing IL-10 expression without inducing high levels of IFN-alpha expression. IL-10-inducing immunostimulatory nucleic acids preferably include a TC dinucleotide at the 5' end and a CG dinucleotide towards the 3' end, but not near the 5' end. The invention is useful for treating and preventing disorders associated with a Th1 or Th2 immune response or for promoting a T regulatory cell environment suitable for suppressing inappropriate immune responses (e.g., for controlling or suppressing excessive immune responses).