发明名称 |
METHOD OF ENGINEERING A CYTIDINE MONOPHOSPHATE-SIALIC ACID SYNTHETIC PATHWAY IN FUNGI AND YEAST |
摘要 |
The present invention provides methods for generating CMP-sialic acid in a non-human host which lacks endogenous CMP-Sialic by providing the host with enzymes involved in CMP-sialic acid synthesis from a bacterial, mammalian or hybrid CMP-sialic acid biosynthetic pathway. Novel fungal hosts expressing a CMP-sialic acid biosynthetic pathway for the production of sialylated glycoproteins are also provided. |
申请公布号 |
WO2005090552(A3) |
申请公布日期 |
2006.01.26 |
申请号 |
WO2005US09095 |
申请日期 |
2005.03.17 |
申请人 |
GLYCOFI, INC.;HAMILTON, STEPHEN, R. |
发明人 |
HAMILTON, STEPHEN, R. |
分类号 |
C12N1/14;C12N1/18;C12N9/10;C12N9/12;C12N9/16;C12N9/88;C12N9/90;C12N15/52;C12N15/81;C12P19/26;C12P21/00 |
主分类号 |
C12N1/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|