摘要 |
The present invention relates to the downregulation of surface receptor CCR5 expression through manipulation of the cell cycle in activated lymphocytes by administering a composition that arrests the G1 phase of the cell cycle, thereby reducing receptor sites for entry of HIV into T cells, and thus, the effects of HIV. Further, a composition is disclosed the includes a G1 phase arresting agent and an antiviral agent, wherein the combination synergically enhances the activity of the antiviral agent. |
申请人 |
UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE;REDFIELD, ROBERT, R.;AMOROSO, ANTHONY;DAVIS, CHARLES, E.;HEREDIA, ALONSA |
发明人 |
REDFIELD, ROBERT, R.;AMOROSO, ANTHONY;DAVIS, CHARLES, E.;HEREDIA, ALONSA |