发明名称 |
METHODS AND ASSAYS FOR DETECTING GUANYLATE CYCLASE ACTIVITY |
摘要 |
<p>The present invention relates to soluble guanylate cyclase (sGC) enzymes. In particular it provides a cell-based assay system which allows to detect with high efficiency and sensitivity the soluble guanylate cyclase enzymatic activity. In a preferred embodiment, the invention provides a method of screening molecules that interact with sGC by stimulating or inhibiting its enzymatic activity and that can be used in the diagnosis or therapy of sGC-mediated dysfunctions or diseases. The invention further provides gene-constructs, vectors, and cells for use in said method.</p> |
申请公布号 |
WO2006007937(A1) |
申请公布日期 |
2006.01.26 |
申请号 |
WO2005EP06887 |
申请日期 |
2005.06.27 |
申请人 |
AXXAM S.R.L;LOHMER, STEFAN;CORAZZA, SABRINA;LIBERATI, CHIARA |
发明人 |
LOHMER, STEFAN;CORAZZA, SABRINA;LIBERATI, CHIARA |
分类号 |
C12Q1/527;G01N33/573;(IPC1-7):C12Q1/527 |
主分类号 |
C12Q1/527 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|