摘要 |
<p>Compositions comprising thrombin and methods of preparing them are disclosed. The composition may be in the form of an aqueous solution at pH 5.7 - 7.4 consisting essentially of 0.1 mg/mL to 5.0 mg/mL thrombin, 2% to 4% (w/v) sucrose, 3.5% to 5% (w/v) mannitol, 50 mM to 300 mM NaCl, 0-5mM CaCl<SUB>2</SUB>, 0.03% to 1% (w/v) of a surfactant or high-molecular-weight polyethylene glycol, and a physiologically acceptable buffer, or may be in lyophilized form.</p> |
申请人 |
ZYMOGENETICS, INC.;JIANG, SHAN;SENDEROFF, RICHARD, I.;MEYER, JEFFREY, D. |
发明人 |
JIANG, SHAN;SENDEROFF, RICHARD, I.;MEYER, JEFFREY, D. |