发明名称 |
METHOD OF PROTECTING SENSITIVE MOLECULES FROM A PHOTOPOLYMERIZING ENVIRONMENT |
摘要 |
In one embodiment, the present invention is a substrate system of photo-polymerizable monomers and bioactive molecules admixed with the monomers and shielded from the monomers by an insoluble material that undergoes a solid-gel transition at body temperature. Upon polymerization, the monomers produce a cross-linked structure and the shielded bioactive molecules are protected from attack in the polymerized environment. In different aspects, the substrate system is used for drug delivery and tissue engineering and protection of enzymes, proteins and growth factors. In another embodiment, the present invention is a drug delivery system of photo-polymerizable monomers, drug molecules associated with the monomers and shielded from the monomers by an insoluble material that undergoes a solid-gel transition at body temperature, and a photopolymerizing means for polymerizing the monomers to produce a cross-linked structure including the drug molecules. |
申请公布号 |
WO2005070467(A3) |
申请公布日期 |
2006.01.26 |
申请号 |
WO2005US00904 |
申请日期 |
2005.01.13 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY;BAROLI, BIANCA;LANGER, ROBERT, S.;SHASTRI, VENKATRAM, PRASAD |
发明人 |
BAROLI, BIANCA;LANGER, ROBERT, S.;SHASTRI, VENKATRAM, PRASAD |
分类号 |
A61K9/00;A61K9/20;A61K47/32;A61K48/00 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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