摘要 |
GnPRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein A, R<SUB>1</SUB>, R<SUB>2</SUB>, R<SUB>3a</SUB>, R<SUB>3b</SUB>, R<SUB>4</SUB>, R<SUB>5</SUB>, R<SUB>6 </SUB>R<SUB>7 </SUB>and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
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