THE PURIFIED LEAF EXTRACT OF GINKGO BILOBA HAVING NEURONAL CELL-PROTECTING ACTIVITY, THE METHOD FOR PREPARING THEM AND THE COMPOSITION COMPRISING THE SAME

摘要

The present invention relates to a novel purified leaf extract of Ginkgo biloba (GBB extract) having neuronal cell protecting activity prepared by inventive method for preparing them and the composition comprising the same having neuronal cell protecting activity for preventing and treating degenerative brain disease. The inventive method of the present invention can provide simpler and cheaper preparation than the conventional preparation method and the inventive extract prepared by the above described inventive method has more safe and effective treating efficacy than the ginkgo leaf extract prepared by the conventional extract by removing unfavorable ingredients which inhibits TF involved in blood coagulation system or shows side effect and increasing advantageous components such as terpene and biflavone showing potent neuro-protective activity. Ac¬ cordingly, it can be used as the therapeutics for treating and preventing neuro-degenerative brain diseases such as stroke, cerebral concussion, Huntington's disease, Creutzfeld- Jakob disease, AIz heimer's disease (AD), Parkinson's disease (PD), senile dementia and the like.