NON-LAMELLAR COMPOSITIONS OF DIOLEOYL PHOSPHATIDYLETHANOLAMINE AND POLYSORBATE 80
摘要
The presene invention relates to particulate compositions comprising at least 50% of dioleoyl phosphatidyl ethanolamine (DOPE) and 1 to 50% of Polysorbate 80 (P80). All parts are by weight relative to the sum of the weights of a+b and the compositions comprise non-lamellar particles or form non-lamellar particles when contacted with an aqueous fluid. The compositions have advantegeous stability and low toxicity and the invention also relates to pharmaceutical compositions thereof.
申请公布号
WO2005070392(A3)
申请公布日期
2006.01.26
申请号
WO2005GB00200
申请日期
2005.01.21
申请人
CAMURUS AB;GODDARD, CHRISTOPHER;BARAUSKAS, JUSTAS;TIBERG, FREDRIK