CRYSTAL OF EGFR EXTRACELLULAR DOMAIN AND CETUXIMAB FAB FRAGMENT AND USES THEREOF
摘要
<p>The present invention relates to co-crystals of cetuximab Fab in a complex with extracellular domain of EGFR, and structure coordinates obtained from such crystal. Such coordinates are useful for identifying mimetics that bind to the extracellular domain of EGFR. Such mimetics may for example inhibit binding of ligand to EGFR, inhibit activation of EGFR, and/or reduce proliferation of tumor cells.</p>
申请公布号
WO2006009694(A2)
申请公布日期
2006.01.26
申请号
WO2005US20969
申请日期
2005.06.14
申请人
IMCLONE SYSETMS INCORPORATED;THE UNIVERSITY OF PENNSYLVANIA;KUSSIE, PAUL, H.;FERGUSON, KATHRYN, M.