摘要 |
The invention provides a compound for use in the prophylaxis or treatment of a disease state or condition mediated by a cyclin dependent kinase, the compound having the formula (I): (I) and salts, tautomers, N-oxides or solvates thereof; wherein A is a bond, C=O, NR<SUP>g</SUP>(C=O) or O(C=O) wherein R<SUP>g</SUP> is hydrogen or C<SUB>1-4</SUB> hydrocarbyl optionally substituted by hydroxy or C<SUB>1-4</SUB> alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; Q is S or CR<SUP>2</SUP>; J is S or CH; provided that one of Q and J is S, and the other of Q and J is not S; when Q is S, there is a double bond between the ring carbon atoms "a" and "b" and a double bond between the ring nitrogen N and J; and when J is S, there is a double bond between Q and the ring carbon atom "a" and a double bond between the ring nitrogen N and the ring carbon atom "b"; and R<SUP>1</SUP> to R<SUP>4</SUP> are as defined in the claims. |
申请人 |
ASTEX THERAPEUTICS LIMITED;BERDINI, VALERIO;EARLY, THERESA, RACHAEL;O'BRIEN, MICHAEL, ALISTAIR;WOODHEAD, ANDREW, JAMES;WYATT, PAUL, GRAHAM |
发明人 |
BERDINI, VALERIO;EARLY, THERESA, RACHAEL;O'BRIEN, MICHAEL, ALISTAIR;WOODHEAD, ANDREW, JAMES;WYATT, PAUL, GRAHAM |