PERFEKTIONIERTE MAGNETISCHE TEILCHEN, VERFAHREN ZU IHRER HERSTELLUNG UND IHRER ANWENDUNGEN ZUM TRENNEN VON MOLEKÜLEN

摘要

The invention concerns magnetic and heat-sensitive particles having a predetermined size between 0.05 and 10 mum, each particle comprising: an inner composite core consisting of a solid organic or inorganic particle, containing within it a magnetic filler; an outer coati based on a polymer capable of interacting with at least a biological molecule, the outer polymer is heat-sensitive and has a predetermined low critical solubility temperature (LCST) ranging between 10 and 100° C. and preferably between 20 and 60° C. The invention also concerns methods for obtaining said particles and their uses. The particles are characterized in that there is an intermediate layer between the inner core and the outer layer isolating said inner core magnetic filler with respect to said functionalized outer layer. Said invention is particularly useful for separating proteins and/or nucleic acids.