发明名称 |
Combinaison comprenant des agents anti-muscariniques et des agonistes béta-adrénergiques |
摘要 |
<p>Combination (I) comprises a phosphodiesterase inhibitor 4 (PDE4) (A) and an antagonist of M3 muscarinic receptors (B) (3(R)-(2-hydroxy-2, 2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo [2.2.2] octane), in the form of a salt having an anion X (anion of a mono or polyvalent acid). An independent claim is also included for a method of treating a patient suffering from or susceptible to a respiratory disease or condition which responds to M3 antagonism comprising simultaneous, concurrent, separate or sequential administration of (I). - ACTIVITY : Antiasthmatic; Respiratory-Gen.; Antiinflammatory. - MECHANISM OF ACTION : Phosphodiesterase-4 inhibitor; Muscarinic receptors antagonist; Leukotriene-D4 antagonist; Neurokinin-1- receptor antagonist; Epidermal growth factor receptor kinase inhibitor; Beta-2 agonist; p38 Kinase inhibitor.</p> |
申请公布号 |
LU91214(A1) |
申请公布日期 |
2006.01.26 |
申请号 |
LU20050091214 |
申请日期 |
2005.05.31 |
申请人 |
ALMIRALL-PRODESFARMA S.A. |
发明人 |
JORDI GRAS ESCARDO;JESUS LLENAS CALVO;PIO ORVIZ DIAS;HAMISH RYDER |
分类号 |
A61K31/137;A61K31/167;A61K31/439;A61K31/573;A61K31/58;A61K31/655;A61K45/00;A61K45/06;(IPC1-7):A61K45/00 |
主分类号 |
A61K31/137 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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