发明名称 |
SPIROPIPERIDINE COMPOUND AND MEDICINAL USE THEREOF |
摘要 |
<p>The present invention relates to a spiro-piperidine compound represented by formula (I):
wherein R 1 represents hydrogen, an aliphatic hydrocarbon group which may have a substituent(s) or a cyclic group which may have a substituent(s); and ring A represents a 5- to 8-membered cyclic group which may have a substituent(s), a salt thereof, an N-oxide thereof, a quaternary ammonium salt thereof or a solvate thereof, or a prodrug thereof The compounds represented by formula (I) have chemokine antagonistic action, so that they are useful for prevention and/or treatment of various inflammatory diseases, immune diseases such as autoimmune diseases or allergic diseases, or HIV infection.</p> |
申请公布号 |
EP1619193(A1) |
申请公布日期 |
2006.01.25 |
申请号 |
EP20040727985 |
申请日期 |
2004.04.16 |
申请人 |
ONO PHARMACEUTICAL CO., LTD. |
发明人 |
NISHIZAWA, RENA;TAKAOKA, YOSHIKAZU;HABASHITA, HIROMU;SHIBAYAMA, SHIRO;KOKUBO, MASAYA |
分类号 |
A61K31/5513;C07D471/10;A61K31/438;A61K31/527;A61K45/06;A61P1/04;A61P1/16;A61P3/10;A61P9/10;A61P11/00;A61P11/02;A61P11/06;A61P13/12;A61P17/00;A61P17/04;A61P17/06;A61P19/02;A61P25/00;A61P27/02;A61P29/00;A61P31/18;A61P35/04;A61P37/02;A61P37/06;A61P37/08;A61P43/00;(IPC1-7):C07D471/10 |
主分类号 |
A61K31/5513 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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