发明名称 |
MOUSE WITH DEFICIENCY OF GLUTAMATE TRANSPORTER GLAST FUNCTION |
摘要 |
<p>The present invention provides a GLAST knockout mouse lacking the function of an endogenous glutamate transporter GLAST gene, which shows: 1) an intraocular pressure within the normal range; and 2) a reduction in the number of cells in the retinal ganglions when compared with a wild-type normal mouse. Owing to the ocular properties, this knockout mouse is useful as a model for normal tension glaucoma. By using this knockout mouse, a compound useful for the treatment of normal tension glaucoma can be screened.</p> |
申请公布号 |
EP1619248(A1) |
申请公布日期 |
2006.01.25 |
申请号 |
EP20040727110 |
申请日期 |
2004.04.13 |
申请人 |
JAPAN SCIENCE AND TECHNOLOGY AGENCY |
发明人 |
TANAKA, KOHICHI;HARADA, TAKAYUKI |
分类号 |
A01K67/027;C12N15/85;(IPC1-7):C12N15/09;G01N33/50;G01N33/15 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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