发明名称 |
Fibrin citrulline derivatives and their use for diagnosing or treating rheumatoid arthritis |
摘要 |
<p>Citrulline (Cit) containing polypeptide (I) derived from all or part of the alpha - or beta -chains of fibrin (from a vertebrate) by substitution of at least one arginine residue by Cit, is new. Independent claims are also included for the following: (1) antigenic composition for detecting autoantibodies (AAb) specific for rheumatoid polyarthritis (RP), comprising at least one (I), optionally labeled and/or conjugated to a carrier protein; (2) method for detecting AAb; (3) kit for detecting AAb; and (4) pharmaceutical composition containing at least one (I) as active ingredient. ACTIVITY : Anti-arthritic; anti-inflammatory. No biological data is given. MECHANISM OF ACTION : Neutralization of an autoimmune response, especially inhibition of fixation of humoral/cellular effectors of the response. The antigen responsible for the autoimmune response in rheumatoid polyarthritis has been identified as citrulline-containing derivatives of fibrin chains.</p> |
申请公布号 |
EP1619205(A1) |
申请公布日期 |
2006.01.25 |
申请号 |
EP20050020523 |
申请日期 |
2000.06.30 |
申请人 |
BIOMERIEUX |
发明人 |
SERRE, GUY;SEBBAG, MIREILLE |
分类号 |
C07K14/75;G01N33/53;A61K38/00;A61P19/02;A61P29/00;A61P37/00;C07K14/47;G01N33/564 |
主分类号 |
C07K14/75 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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