PERCUTANEOUS ABSORPTION TYPE PREPARATION

摘要

A percutaneous absorption type preparation comprising a support and a plaster layer laminated thereon, which comprises tulobuterol in a proportion of not less than 5 wt% in a dissolution state and an adhesive. The preparation of t he present invention retains the active ingredient, tulobuterol, at a high concentration in a complete dissolution state in the plaster layer. Therefore, it is free of time- course changes in drug releasing property and adhesive property caused by precipitation of drug crystals with the lapse of time. The inventive preparation is superior in percutaneous absorption of the drug, particularly percutaneous absorption rate at the initial stage of the administration; shows superior duration of efficacy by maintaining effective blood concentration for a long time; an d is associated with less changes with the lapse of time in adhesive property suc h as adhesion to the skin.