发明名称 |
HUMANIZED ANTIBODY SPECIFIC FOR SURFACE ANTIGEN PRE-S1 OF HBV AND PREPARATION METHOD THEREOF |
摘要 |
The present invention relates to humanized antibodies specific for HBV surface antigen pre-S1, which show binding affinity similar to mouse monoclonal antibody and which show remarkably reduced immunogenicity since they have less mouse-derived amino acid residues. Thus, the humanized antibodies of the present invention may be useful for the prevention of HBV infection and for the treatment of hepatitis B.
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申请公布号 |
CA2351315(C) |
申请公布日期 |
2006.01.24 |
申请号 |
CA19992351315 |
申请日期 |
1999.11.19 |
申请人 |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY;KOREA GREEN CROSS CORPORATION |
发明人 |
HUR, HYANGSUK;RYU, CHUN JEIH;HONG, HYO JEONG |
分类号 |
C12N15/09;C12N15/13;A61K39/395;A61P1/16;A61P31/20;C07K16/08;C12N15/51;C12N15/62;C12N15/63;C12P21/08 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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