发明名称 |
2'-BRANCHED NUCLEOSIDES AND FLAVIVIRIDAE MUTATION |
摘要 |
The present invention discloses a method for the treatment of Flaviviridae infection that includes the administration of a 2′-branched nucleoside, or a pharmaceutically acceptable prodrug and/or salt thereof, to a human in need of therapy in combination or alternation with a drug that directly or indirectly induces a mutation in the viral genome at a location other than a mutation of a nucleotide that results in a change from serine to a different amino acid in the highly conserved consensus sequence, XRXSGXXXT (SEQ ID NO: 63), of domain B of the RNA polymerase region, or is associated with such a mutation. The invention also includes a method to detect a mutant strain of Flaviviridae and a method for its treatment. |
申请公布号 |
PL377342(A1) |
申请公布日期 |
2006.01.23 |
申请号 |
PL20030377342 |
申请日期 |
2003.11.17 |
申请人 |
IDENIX (CAYMAN) LIMITED;UNIVERSITA DEGLI STUDI DI CAGLIARI |
发明人 |
SOMMADOSSI JEAN-PIERRE;LA COLLA PAOLO;STANDRING DAVID;BICHKO VADIM;QU LIN |
分类号 |
C12N15/40;A61K31/7052;A61K38/21;A61K39/12;A61K45/06;C07H19/06;C07H19/16;C07K14/18;C12Q1/70 |
主分类号 |
C12N15/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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