| 摘要 |
A spiro compound represented by the following formula (I) <CHEM> wherein R<1> and R<2> are the same or different and each is a hydrogen atom, a chlorine atom and the like, n is 1, 2 or 3, a bond containing a broken line is a single bond or a double bond, A is -X-(CH2)q-N(R<3>)(R<4>); a group represented by the following formula (a) <CHEM> and the like, wherein X is an oxygen atom or a sulfur atom, q is 2 or 3, R<3> and R<4> are the same or different and each is a C1-6 alkyl group and the like, or R<3> and R<4> optionally form, together with the adjacent nitrogen atom, a piperidine ring and the like optionally substituted by one or two C1-6 alkyl and the like, R<5> is a C1-6 alkyl group and the like, R<6> is a hydrogen atom and the like, and r and t are each independently one or two, or a pharmaceutically acceptable acid addition salt thereof. The compound is useful as a selective estrogen receptor modulator having a climacteric syndrome-ameliorating effect, and can be expected to be a drug for the prophylaxis and/or treatment of osteoporosis, climacteric syndrome and breast cancer. |
