CLEAVAGE OF VEGF AND VEGF RECEPTOR BY WILD-TYPE AND MUTANT PROTEASES
摘要
Disclosed herein are methods for creating and using mutein proteases with altered specificity for the target molecules they cleave. The invention further discloses methods of using wild-type and mutein granzyme B to target VEGFR proteins to treat diseases, such as cancer. Cleaving VEGFR at certain substrate sequences with wild-type and mutein granzyme B proteases is a method for treating pathologies associated with angiogenesis.
申请公布号
WO2005100556(A3)
申请公布日期
2006.01.19
申请号
WO2005US12243
申请日期
2005.04.12
申请人
CATALYST BIOSCIENCES;RUGGLES, SANDRA, WAUGH;NGUYEN, JACK