DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH CORTICOTROPIN RELEASING HORMONE RECEPTOR 2 (CRHR2)

摘要

The invention provides a human CRHR2 which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, metabolic diseases, hematological disorders, neurological disorders, urological disorders, respiratory diseases, cancer disorders and reproduction disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, metabolic diseases, hematological disorders, neurological disorders, urological disorders, respiratory diseases, cancer disorders and reproduction disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of CRHR2 as well as pharmaceutical compositions comprising such compounds.