OLIGONUCLEOTIDE COMPOUND AND METHOD FOR TREATING NIDOVIRUS INFECTIONS
摘要
A method and oligonucleotide compound for inhibiting replication of a nidovirus in virus-infected animal cells are disclosed. The compound (i) has a nuclease-resistant backbone, (ii) is capable of uptake by the infected cells, (iii) contains between 8-25 nucleotide bases, and (iv) has a sequence capable of disrupting base pairing between the transcriptional regulatory sequences in the 5' leader region of the positive-strand viral genome and negative-strand 3' subgenomic region. In practicing the method, infected cells are exposed to the compound in an amount effective to inhibit viral replication.
申请公布号
WO2005065268(A3)
申请公布日期
2006.01.19
申请号
WO2004US43341
申请日期
2004.12.23
申请人
AVI BIOPHARMA, INC.;STEIN, DAVID, A.;BESTWICK, RICHARD, K.;IVERSEN, PATRICK, L.;NEUMAN, BENJAMIN;BUCHMEIER, MICHAEL
发明人
STEIN, DAVID, A.;BESTWICK, RICHARD, K.;IVERSEN, PATRICK, L.;NEUMAN, BENJAMIN;BUCHMEIER, MICHAEL