ORAL DELIVERY OF PEPTIDE PHARMACEUTICAL COMPOSITIONS
摘要
Bioavailability of peptide active agents to be administered orally is enhanced by a pharmaceutical composition providing targeted release of the peptide to the intestine by combining the composition with an absorption enhancer. Bioavailability is further significantly increased by administering the composition in an acid-resistant protective vehicle which transports components of the invention through the stomach. The composition may optionally further include a sufficient amount of a pH-lowering agent to lower local intestinal pH. All components are released together into the intestine with the peptide.
申请公布号
WO2006007332(A1)
申请公布日期
2006.01.19
申请号
WO2005US20255
申请日期
2005.06.09
申请人
UNIGENE LABORATORIES, INC.;MEHTA, NOZER M.;STERN, WILLIAM;GILLIGAN, JAMES P.