发明名称 |
Peptides and compounds that bind to the IL-5 receptor |
摘要 |
New IL-5 receptor antagonists and methods of use are described, e.g., in the treatment of IL-5 receptor mediated disorders. The compounds include both monomers and dimers that were identified using one or more of alanine scans, lysine scans, other residue substitutions, and C- and N-terminal truncations and additions vis a vis the core sequence Val Asp Glu Cys Trp Arg Ile Ile Ala Ser His Thr Trp Phe Cys Ala Glu Glu-AF17121 (SEQ ID NO: 1) and shorter sequences and derivatives thereof.
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申请公布号 |
US2006014680(A1) |
申请公布日期 |
2006.01.19 |
申请号 |
US20040890546 |
申请日期 |
2004.07.13 |
申请人 |
XU CAIDING;YANG LYDIE;BHANDARI ASHOK;HOLMES CHRIS;CHEN MIN-JIA;SCHATZ PETER;BALU PALANI |
发明人 |
XU CAIDING;YANG LYDIE;BHANDARI ASHOK;HOLMES CHRIS;CHEN MIN-JIA;SCHATZ PETER;BALU PALANI |
分类号 |
A61K38/16;A61K38/08;A61K38/10;C07K7/08;C07K7/64 |
主分类号 |
A61K38/16 |
代理机构 |
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