Arylalkylcarbamate derivatives production and use thereof in therapy

摘要

Compound of the general formula (I) in which n represents an integer ranging from 1 to 7; A is selected from the group consisting of X, Y and Z; X represents a C_1-2-alkylene group optionally substituted by one or more C_1-12-alkyl, C_3-7-cycloalkyl or C_3-7-cycloalkyl-C_1-6-alkylene groups; Y represents a C₂-alkenylene group optionally substituted by one or more C_1-12-alkyl, C_3-7-cycloalkyl or C_3-7-cycloalkyl-C_1-6-alkylene groups; Z represents a C_3-7-cycloalkyl group of formula: m represents an integer ranging from 1 to 5; p and q represent integers and are defined such that p+q is a number ranging from 1 to 5; R₁ represents a hydrogen or halogen or a hydroxyl, cyano, nitro, C_1-4-alkyl, C_1-4-alkoxy, C_1-4-thioalkyl, C_1-4-fluoroalkyl, C_1-4-fluoroalkoxy or C_1-4-fluorothioalkyl group; R₂ represents a hydrogen or halogen or a cyano, nitro, hydroxyl, C_1-4-alkyl, C_1-4-alkoxy, C_1-4-thioalkyl, C_1-4-fluoroalkyl, C_1-4-fluoroalkoxy, C_1-4-fluorothioalkyl group, or an aryl-type or heteroaryl-type group optionally substituted by one or more substituents; R₃ represents a group of general formula CHR₄CONHR₅ in which R₄ represents a hydrogen or a C_1-3-alkyl group and R₅ represents a hydrogen or a C_1-3-alkyl, C_3-5-cycloalkyl or C_3-7-cycloalkyl-C_1-6-alkylene group; in the form of the base, acid addition salt, hydrate or solvate.