发明名称 |
CELL DEATH-INDUCING FUSED GENE ACTING SPECIFICALLY ON CANCER AND GENE PRODUCT THEREOF |
摘要 |
<p>The present invention provides a protein having a potent cell-death inducing activity that is, a fused protein is in which a modified Bax protein fused with GFP at the N-terminus and is further fused with a homing signal peptide having a homing activity specific for endothelial cells in tumor angiogenesis; a gene coding the fused protein; and a cancer cell growth inhibitor containing the fused protein. Namely, a fused gene containing a cell death-inducing gene acting specially on cancer tissue, which is a fused gene having a gene encoding a homing signal peptide sequence specific for endothelial cells undergoing angiogenesis, a gene encoding a green fluorescent protein (GFP) and a gene encoding ”NBax protein, which is human Bax with a deletion of the N-terminal sequence containing the BH3 domain in this order, and a fusion protein encoded by the fused gene.</p> |
申请公布号 |
EP1616956(A1) |
申请公布日期 |
2006.01.18 |
申请号 |
EP20040722640 |
申请日期 |
2004.03.23 |
申请人 |
NIPPON MEDICAL SCHOOL FOUNDATION |
发明人 |
OHTA, SHIGEO;ASOH, SADAMITSU |
分类号 |
C07K14/47;A61K38/00;A61P35/00;C07K7/06;(IPC1-7):C12N15/62;C12P21/02;C07K19/00;C07K14/44;A61K38/16 |
主分类号 |
C07K14/47 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|