发明名称 |
USE OF DERIVATIVES OF 2,4-DIHYDRO-[1,2,4]TRIAZOLE-3-THIONE AS INHIBITORS OF THE ENZYME MYELOPEROXIDASE(MPO) |
摘要 |
There is disclosed the use of a compound of formula (I) wherein X, Y, W and Q are as defined in the specification, and pharmaceutically acceptable salts thereof, in the manufacture of a medicament, for the treatment or prophylaxis of diseases or conditions in which inhibition of the enzyme myeloperoxidase (MPO) is beneficial. Certain novel compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed, together with processes for their preparation. The compounds of formulae (I) are MPO inhibitors and are thereby particularly useful in the treatment or prophylaxis of neuroinflammatory disorders.
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申请公布号 |
KR20060006064(A) |
申请公布日期 |
2006.01.18 |
申请号 |
KR20057020226 |
申请日期 |
2005.10.24 |
申请人 |
ASTRAZENECA AB |
发明人 |
SVENSSON MATS;TIDEN ANNA KARIN;TUREK DOMINIKA |
分类号 |
A61K31/4196;A61P25/16;A61P25/28;C07D249/12;C07D401/04;C07D401/06;C07D403/04;C07D403/06;C07D405/04;C07D405/06;C07D409/04;C07D409/06;C07D413/04;C07D417/04 |
主分类号 |
A61K31/4196 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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