SUBSTITUTED BENZENESULFONYLUREAS AND -THIOUREAS, PREPARATIONPROCESSES AND POSSIBLE USES OF PHARMACEUTICAL PREPARATIONS BASED ON THESE COMPOUNDS

摘要

Substituted benzenesulfonylureas and -thioureas as Antiarrhythmics Benzenesulfonylureas and -thioureas of the formula I <IMG> where R(1) is H or (cyclo)(CH2)a(fluoro)alk(en)yl, R(2) is H, Hal, (fluoro)(mercapto)(CH2)e(cyclo)alk(oxy)(yl) or NR(4)R(5), where R (4) and R (5) together are a (CH2) 2-7 chain, or R (4) , R (5) and R ( 6) are H or (alkyl)(cyclo)(fluoro)alk(en)yl, E is O or S; Y is -[CR(7)2]n- R(3) is <IMG> B is (C3-C6)-alkenyl, or R(3) is <IMG> X is H, Hal or alkyls; Z is Hal or (cyclo)-alk(yl)oxy. Compounds I are used for treatment of disturbances in cardiac rhythm and prevention of sudden cardiac death caused by arrhythmia, and can therefore be used as antiarrhythmics. They are particularly suitable for those cases where arrhythmias are a consequence of a narrowing of a coronary vessel, such as angina pectoris or acute cardiac infarction.