发明名称 |
Aripiprazole, olanzapine and haloperidol pamoate salts |
摘要 |
The invention relates to the discovery that pamoate salts of haloperidol and aripiprazole result in a good to superior long acting and/or extended release profile. Thus, in one aspect of the invention, the invention includes pamoate salts of haloperidol or aripiprazole. Preferably, the pamoate salt is characterized by a ratio of haloperidol to pamoate of 1:1 or 2:1. The pamoate salt can be crystalline, such as a needle or a dense crystal, such as described in the Figures. The invention further relates to methods of treating an individual in need thereof comprising administering a pharmaceutical composition comprising a pamoate salt of haloperidol and aripiprazole.
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申请公布号 |
US6987111(B2) |
申请公布日期 |
2006.01.17 |
申请号 |
US20030635232 |
申请日期 |
2003.08.06 |
申请人 |
ALKERMES CONTROLLED THERAPEUTICS, II |
发明人 |
GRECO KRISTYN;WRIGHT JAMES |
分类号 |
A61K31/445;A61K31/495;C07D211/52 |
主分类号 |
A61K31/445 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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