Bisarylsulfonamide compounds and their use in cancer therapy

摘要

The present invention relates to the use of bisarylsulfonamide compounds of formula I wherein W is a C_1-5 branched or unbranched alkyl group or a C_2-5 alkenyl group; n is 0 or 1; R¹ is H, a C_1-8 branched or unbranched alkyl group, a C_2-8 alkenyl group, or an aryl or aralkyl group; Ar¹ is a substituted thienyl, furyl, pyrrolyl, imidazothiazolyl, thiazolyl, pyridyl or phenyl group; and Ar² is a substituted phenyl, indolyl or benzoimidazolyl group; in the preparation of a medicament for treating proliferative disorders. Further aspects of the invention relate to compounds of formula I, pharmaceutical compositions thereof, and an assay for determining binding to HDM2.