Administration of therapeutic viruses

摘要

There is provided a negative-stranded RNA virus for use in a method of treating a subject, wherein said method comprises administering the negative-stranded RNA virus to the subject in a cycle comprising one or more doses of the virus, wherein the first dose is administered over an administration time period of up to 24 hours, and wherein said first dose is administered at a rate of up to 3.0 x 10 9 PFU per square meter of patient surface area in any ten minute sampling time period within the administration time period. There is also provided a negative-stranded RNA virus for use in a method of treating a subject, wherein said method comprises administering the negative-stranded RNA virus to the subject in a cycle comprising two or more doses of the virus, wherein the second or subsequent dose is administered over an administration time period of up to 24 hours, and wherein said second or subsequent dose is administered at a rate of up to 5.0 x 10 10 PFU per square meter of patient surface area in any ten minute sampling time period within the administration time period.