METHOD FOR PRODUCING OPTICALLY ACTIVE CYCLOPROPANECARBOXYLATE COMPOUND

摘要

A method for producing an optically active cyclopropanecarboxylate compound represented by the following formula (5): (wherein R⁶, R⁷, R⁸, R⁹ and R¹⁰ are as defined below) is disclosed which is characterized by reacting an olefin represented by the following formula (3): (wherein R⁶, R⁷, R⁸ and R⁹ respectively represent an alkyl group having 1-6 carbon atoms or the like) and a diazoacetate represented by the following formula (4): N² CHCO₂ 10 (4) (wherein R¹⁰ represents an alkyl group having 1-6 carbon atoms) in the presence of an asymmetric copper complex obtained by mixing (A) at least one monovalent or divalent copper compound, (B) at least one optically active bisoxazoline compound represented by the following formula (1): (wherein R¹ and R² respectively represent an alkyl group having 1-6 carbon atoms or the like, R³ represents a tert-butyl group or the like, and R⁴ and R⁵ are the same and respectively represent an alkyl group having 1-3 carbon atoms or the like), and (C) at least one fluorine compound represented by the following formula (2): A--MF⁶ (2) (wherein A represents a trityl group or the like, and M represents a phosphorus atom or the like).