| 摘要 |
Respective hollow fiber membranes suitable for use in removing undesired contaminants from blood, in particular in an artificial kidney, have: (1) per membrane area of 1.6 m<2>, in vitro clearances for urea and phosphorus respectively of≥195, and≥180, ml/min, a beta 2-microglobulin clearance≥44 ml/min and an albumin permeability≤0.5%; (2) an albumin permeability≤1.5% and an overall mass transfer coefficient Ko≥0.0012 cm/min; and (3) a vitamin B12 dialyzance of≥135 ml/min and an albumin permeability≤3%. The membranes can be prepared by spinning hollow fibers from a spinning solution comprising a polysulfone, a hydrophilic polymer, a solvent and water, the spinning solution having a viscosity x at 30 DEG C of 25-130 poise and a quantity y % of water given by: <MATH> The membranes can be incorporated into a hemodialyzer module by a method in which they are preimpregnated with a wetting agent, thereafter kept separate from one another by spacers and then inserted in the module. |
