UREA DERIVATIVE

摘要

A urea derivative having excellent DGAT inhibitory activity or a pharmacologically acceptable salt thereof. The urea derivative is represented by the general formula (I) (II) (III) (XXXIX) (XL) [wherein R<SUP>1</SUP> is, e.g., C<SUB>6-10 </SUB>aryl optionally substituted independently by one to five groups selected from substituent groups (a); R<SUP>2</SUP> is, e.g., C<SUB>6-10</SUB> aryl optionally substituted independently by one to five groups selected from substituent groups (a); E is, e.g., a group having the formula (II) or (III) (wherein R<SUP>3</SUP> is hydrogen, etc.; R<SUP>4</SUP> and R<SUP>5</SUP> are the same or different and each is hydrogen, etc.; X and U are the same or different and each is CH, etc.; and m and n are the same or different and each is 1, etc.); and A is -NH-C(=O)-, etc.].