Antiproliferative 1,2,3-thiadiazole compounds

摘要

This invention is directed to methods of using compounds having the structure: and including stereoisomers, solvates, and pharmaceutically acceptable salts thereof, wherein each of R¹, R², R³ and R⁴ is independently selected from hydrogen, R⁵, R⁶, and R⁷; R⁵ is selected from alkyl, heteroalkyl, aryl and heteroaryl; R⁶ is selected from (R⁵)_n-alkylene, (R⁵)_n-heteroalkylene, (R⁵)_n-arylene and (R⁵)_n-heteroarylene; R⁷ is selected from (R⁶)_n-alkylene, (R⁶)_n-heteroalkylene, (R⁶)_n-arylene, and (R⁶)_n-heteroarylene; and n is selected from 0, 1, 2, 3, 4 and 5, where R¹ and R² may together form a heterocyclic structure including the nitrogen to which they are both attached, and R³ and R⁴ may together form a heterocyclic structure including the nitrogen to which they are both attached; and each of L¹ and L² is independently selected from -A1-A2-A3- where each of A1, A2, and A3 is independently selected from a direct bond, alkylene, heteroalkylene, arylene and heteroarylene. These compounds are useful in treating hyperproliferative disorders and inducing apoptosis.