<p>The construction of recombinant respiratory syncytial virus (RSV) strains deleted of the region of G protein most likely to induce unwanted type 2 T cell responses in susceptible recipients is disclosed. Using reverse genetics, recombinant RSV strains were engineered with deletions of amino acids 151-221 and 178-219. Both RSV strains replicated in the respiratory tract of BALB/c mice and elicited serum neutralization and anti-F protein IgG titers that were equivalent to cp-RSV and contributed to a 3.9 log<sub</p>
申请公布号
WO2006004874(A1)
申请公布日期
2006.01.12
申请号
WO2005US23181
申请日期
2005.06.29
申请人
WYETH HOLDINGS CORPORATION;HANCOCK, GERALD, E., PH., D.;ELLIOTT, MATTHEW, B.