<p>The present invention broadly relates to the attenuation of herpes simplex virus type 2 (HSV-2). More particularly, the invention relates to the identification of mutations in the HSV-2 U<SUB>L</SUB>24 gene which attenuate the pathogenicity of HSV vectors in mammals and immunogenic compositions thereof.</p>
申请公布号
WO2006004878(A1)
申请公布日期
2006.01.12
申请号
WO2005US23185
申请日期
2005.06.28
申请人
WYETH;VISALLI, ROBERT, J.;KOWALSKI, JACEK;NATUK, ROBERT, J.;BLAKENEY, SUSAN, J.
发明人
VISALLI, ROBERT, J.;KOWALSKI, JACEK;NATUK, ROBERT, J.;BLAKENEY, SUSAN, J.
