发明名称 |
METHOD OF OBTAINING 2-AMINO-6-ALKYL-AMINO-4,5,6,7-TETRAHYDROBENZOTHIAZOLES |
摘要 |
<p>The invention relates to a method of preparing 2-amino-6-alkyl-amino-4,5,6,7-tetrahydrobenzothiazoles having formula (I), wherein the asterisk (*) represents an asymmetrical carbon and R<SUP>1</SUP> is alkyl C<SUB>1</SUB>-C<SUB>6</SUB>, the enantiomers or mixtures thereof, the pharmaceutically-acceptable solvates, hydrates or salts of same. The inventive method comprises the following steps consisting in: (a) reacting a compound (II) with a secondary amine, optionally in the presence of an acid and a solvent 1, in order to form an enamine; (b) optionally removing the acid and solvent 1 and, subsequently, reacting the enamine with sulphur in the presence of a solvent 2; and (c) reacting the previously obtained compound with cyanamide in order to obtain compound (I). Compounds having formula (I) include pramipexol which is a compound with dopamine D2 agonist activity that can be used for the treatment of Parkinson's disease and schizophrenia.</p> |
申请公布号 |
WO2006003220(A1) |
申请公布日期 |
2006.01.12 |
申请号 |
WO2005ES00362 |
申请日期 |
2005.06.24 |
申请人 |
RAGACTIVES, S.L.;PASCUAL COCA, GUSTAVO;MARTIN JUAREZ, JORGE |
发明人 |
PASCUAL COCA, GUSTAVO;MARTIN JUAREZ, JORGE |
分类号 |
(IPC1-7):C07D277/82;C07C211/40;A61K31/429;A61P25/18;A61P25/28;C07C225/20;C07C321/22 |
主分类号 |
(IPC1-7):C07D277/82 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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