| 摘要 |
PROBLEM TO BE SOLVED: To provide a treatment approach which inhibits a fatal reaction of severe pneumonia, and at the same time which makes potentially severe adverse side effects minimum. SOLUTION: The method of treating or preventing severe pneumonia comprises administration of TFPI or a TFPI analog to a patient who has or who is at risk of having severe pneumonia, wherein the above TFPI analog is non-glycosylated ala-TFPI, the above patient has a demonstrable infection, and the above TFPI or TFPI analog is administered by continuous intravenous infusion at a dose rate equivalent to administration of reference ala-TFPI at a dose rate of less than about 0.66 mg/kg/hr. COPYRIGHT: (C)2006,JPO&NCIPI
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