CELL-INDEPENDENT FABRICATION OF TISSUE EQUIVALENTS
摘要
This invention relates to cell-independent processes which mimic cellular bioremodelling and produce organised biomaterials which have mechanical properties and viable cell densities suitable for use as functional tissue implants. The biomaterials are produced by providing a gel comprising a matrix of scaffold fibres of and an interstitial fluid; and plastically compacting the gel to produce the biomaterial. The biomaterials may comprise 3D structures such as layering, alignment and meso-scale zonal heterogeneities of cells and matrix which mimic native tissue structure. Biomaterials with biomimetic structure as described herein may be useful in a range of therapeutic applications.
申请公布号
WO2006003442(A2)
申请公布日期
2006.01.12
申请号
WO2005GB02631
申请日期
2005.07.05
申请人
UCL BIOMEDICA PLC;BROWN, ROBERT;NAZHAT, SHOWAN;MUDERA, VIVEK;WISEMAN, MIKE
发明人
BROWN, ROBERT;NAZHAT, SHOWAN;MUDERA, VIVEK;WISEMAN, MIKE