摘要 |
Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of the dimeric mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology. |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM? |
发明人 |
HARRAN, PATRICK, G.;WANG, XIAODONG;DE BRABANDER, JEF, K.;LI, LIN;THOMAS, RANNY, MATHEW;SUZUKI, HIDETAKA |